Sudo chmod u+s /Applications/OpenSource/VirtualBox.app/Contents/MacOS/VBoxHeadless Sudo chmod u+s /Applications/OpenSource/VirtualBox.app/Contents/MacOS/VirtualBoxVM Sudo chmod u+s /Applications/OpenSource/VirtualBox.app/Contents/MacOS/VirtualBox Sudo chown -R root:admin /Applications/OpenSource/VirtualBox.app/ Now make sure that the setuid stubs have the correct permissions: There isn't any support for installing VirtualBox into a target directory.
Next rebuild VirtualBox and install it into /Applications/OpenSource/. You can prevent that by adding the following to LocalConfig.kmk: Starting with VirtualBox 4.1, extra debug symbols are created. It may also make sense to disable some of the development only stuff, like test cases. VBOX_PATH_APP_DOCS = "/Applications/OpenSource/VirtualBox.app/Contents/MacOS" VBOX_PATH_SHARED_LIBS = "/Applications/OpenSource/VirtualBox.app/Contents/MacOS" VBOX_PATH_APP_PRIVATE_ARCH = "/Applications/OpenSource/VirtualBox.app/Contents/MacOS" VBOX_PATH_APP_PRIVATE = "/Applications/OpenSource/VirtualBox.app/Contents/MacOS" If you like to change that, say into /Applications/OpenSource/VirtualBox.app/, you need to add the following to the LocalConfig.kmk: The default install directory of VirtualBox is /Applications/VirtualBox.app/. Hardening needs some additional configuration and post-build steps. Never disable hardening (see previous section) when creating packages for redistribution.